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First to array the entire SARS
genome encoded peptides and to map SARS-specific epitopes.
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Discovered a series of candidate
peptides effectively blocking P-Glycoprotein and increasing
intracellular concentration of chemotherapeutics.
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Discovered a series of candidate
peptides effectivley inhibiting reverse transcriptase. The encoded
DNA transfected cells inhibited HIV viral replication.
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Mapped tau-tau specific binding
regions on tau protein, which can become targets for developing
drugs treating Alzheimer's disease.
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Discovered a peptide which inhibits
carboxypeptidase R activity and dramatically reduces fibrinolysis
time when combined with tissue plasminogen activator for treating
thrombosis.
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High throughput sera screening
in identifying biomarkers for early cancer diagnosis.
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High throughput sample screening
in identifying biological fingerprints for the development of
quality control tests and detection of hazardous substances.
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Generation of peptide antibody
mimetics to HER2 for treatment of breast cancer.
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Discovery of peptides inhibiting
tyrosinase and melanin synthesis, which can be developed into
a skin pigment lightening product.
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Discovery of peptides inhibiting
protein activity in presynaptic neurons and release of acetylcholine.
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